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Science news... buy viagra canada From universities, journals, and other research organizations  save  email  print  share disruption of cytoskeleton pathways contribute to amyotrophic lateral sclerosis pathogenesis sciencedaily (july 15, 2012) — a new genetic mutation that causes familial amyotrophic lateral sclerosis (als), a fatal neurological disorder also known as lou gehrig's disease, has been identified by a team of scientists led by researchers at the university of massachusetts medical school (umms). viagra 5mg or 20 mg Mutations to the profilin (pfn1) gene, which is essential to the growth and development of nerve cell axons, is estimated to account for one to two percent of inherited als cases. cheap viagra The finding, described july 15 in the online edition of nature, points to defects in a neuron's cytoskeleton structure as a potential common feature among diverse als genes. viagra dosage compared to viagra Share this: see also: health & medicine amyotrophic lateral sclerosis nervous system chronic illness genes parkinson's research gene therapy reference sensory neuron spinal muscular atrophy huntington's disease motor neuron "this discovery identifies what may possibly be a common biological mechanism involved across familial als cases regardless of genetics," said john landers, phd, associate professor of neurology and senior author of the study. best retail pharmacy viagra price "we know of at least three other als genes, in addition to pfn1, that adversely impact axon growth. generic viagra If indeed, this is part of the disease's mechanism, then it might also be a potential target for therapeutics. viagra patent expiry canada " robert brown, md, dphil, a co-author on the study and chair of neurology at umass medical school, said "dr. viagra patent expiry canada Landers has done great work in defining this new pathway for motor neuron death. viagra cost We are delighted to have identified the defects in families from the u. S. , israel and france that we have been investigating for several years. Our finding is particularly exciting because it may provide new insights into als treatment targets. " als is a progressive, neurodegenerative disorder affecting the motor neurons in the central nervous system. viagra patent expiry canada As motor neurons die, the brain's ability to send signals to the body's muscles is compromised. This leads to loss of voluntary muscle movement, paralysis and eventually respiratory failure. The cause of most cases of als is not known. viagra coupon Approximately 10 percent of cases are inherited. can we get viagra over the counter Though investigators at umass medical school and elsewhere have identified several genes shown to cause inherited or familial als, almost 50 percent of these cases have an unknown genetic cause. The current nature study details the discovery of the pfn1 gene mutation among two large als families. Both families were negative for known als-causing mutations and displayed familial relationships that suggested a dominant inheritance mode for the disease. ordering viagra online without visiting a doctors   
 
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